Curcumin protects against bisphenol A‐induced hepatic steatosis by inhibiting cholesterol absorption and synthesis in <scp>CD</scp>‐1 mice

Curcumin is a polyphenol extracted from the rhizome of turmeric, and our previous research showed that curcumin inhibited cholesterol absorption had cholesterol-lowering effect. Bisphenol A (BPA), common plasticizer, widely used in manufacture food packaging associated with non-alcoholic fatty liver disease (NAFLD). We hypothesized could protect against BPA-induced hepatic steatosis by inhibiting synthesis. Male CD-1 mice fed BPA-contaminated diet or without for 24 weeks were to test hypothesis. found chronic low-dose BPA exposure significantly increased levels serum triglyceride (TG), total (TC), low-density lipoprotein contents TG TC, resulting fat accumulation while supplementation alleviate dyslipidemia steatosis. Moreover, anti-steatosis effects coincided significant reduction intestinal synthesis, which was modulated suppressing expression sterol regulatory element-binding protein-2 (SREBP-2), Niemann–Pick C1-like 1 (NPC1L1), 3-hydroxy-3-methylglutaryl coenzyme reductase (HMGCR) small intestine liver. In addition, lipogenic genes such as X receptor alpha (LXRα), SREBP-1c, acetyl-CoA carboxylase (ACC1), ACC2 also markedly down-regulated curcumin. Overall, findings indicated synthesis SREBP-2, NPC1L1, HMGCR expression, subsequently reducing thereby preventing NAFLD.