Current Approaches in NSCLC Targeting K-RAS and EGFR

EGFR and K-ras mutations in cytologic samples from fine-needle aspirates in NSCLC patients.

1 Bush A, Hedlin G, Carlsen KH, et al. Severe childhood asthma: a common international approach? Lancet 2008; 372: 1019–1021. 2 Hedlin G, Bush A, Lødrup Carlsen K, et al. Problematic severe asthma in children, not one problem but many: a GALEN initiative. Eur Respir J 2010; 36: 196–201. 3 Lang AM, Konradsen J, Carlsen KH, et al. Identifying problematic severe asthma in the individual child – do...

Silibinin Inhibits NSCLC Metastasis by Targeting the EGFR/LOX Pathway

Tumor metastasis is the most lethal and debilitating process that threatens cancer patients. Among the regulators involved in tumor metastasis, lysyl oxidase (LOX) is an important contributor for tumor invasion, migration and the formation of the pre-metastatic niche. Although the relationship between LOX and poor prognosis of lung patients has been preliminary reported, the mechanism remains p...

EGFR expression in NSCLC

E pidermal growth factor receptor (EGFR), a receptor tyrosine kinase, is frequently overexpressed in nonsmall cell lung cancer (NSCLC). These receptors play an important role in tumour cell survival and activated phosphorylated EGFR results in the phosphorylation of downstream proteins that cause cell proliferation, invasion, metastasis, and inhibition of apoptosis. Expression appears to be dep...

Current Therapeutic Advances Targeting EGFR and EGFRvIII in Glioblastoma

Epidermal growth factor receptor (EGFR) and EGFRvIII analysis is of current interest in glioblastoma - the most common malignant primary CNS tumor, because of new EGFRvIII vaccine trials underway. EGFR activation in glioblastoma promotes cellular proliferation via activation of MAPK and PI3K-Akt pathways, and EGFRvIII is the most common variant, leading to constitutively active EGFR. This revie...

Pl1: Targeting K-ras Driven Lung and Pancreatic Tumors