Cyberknife re-irradiation for recurrent glioblastoma multiforme

Role of Re-irradiation in Salvage Treatment of Glioblastoma Multiforme.

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in humans, accounting for 12-15% of all brain tumors. The first therapeutic approache in this tumor is to perform maximal surgical resection with preserving neurologic functions. Currently,adjuvant radiotherapy (combined with chemotherapy or alone) following surgery is the standard treatment with proven positive...

Bevacizumab for recurrent glioblastoma multiforme

Reoperation for Recurrent Glioblastoma Multiforme.

The role of reoperation for glioblastoma multiforme (GBM) recurrence is currently unknown. However, multiple studies have indicated that survival and quality of life are improved with a repeat operation at the time of disease recurrence. Prognosis is likely interdependent on several factors, including age, functional status, initial resection status, disease location, and surgical efficacy. How...

PCV chemotherapy for recurrent glioblastoma multiforme.

The authors evaluated response, time to progression (TTP), survival, prognostic factors, and toxicity in 63 patients with a recurrent glioblastoma multiforme treated with procarbazine, lomustine, and vincristine (PCV) chemotherapy. Complete and partial response was observed in two (3%) and five patients (8%). In 16 patients (25%), stable disease was observed. Median TTP and survival were 13 and...

Radiothermotherapy for glioblastoma multiforme: A preliminary study

Introduction: Glioblastoma multiforme (GBM) is a highly radioresistant cancer with low survival rate. Current therapy approaches have failed to treat GBM. The aim of this study was to assess how GBM tumors respond to combination of hyperthermia and radiotherapy. Materials and Methods:   In this study, 38 GBM patients were included. 19 patients were treated ...