CYP2C19 gene polymorphism and its impact on the long-term prognosis after myocardial infarction
نویسندگان
چکیده
Background: Despite advanced in interventional and medical treatment, mortality after myocardial infarction (MI) remains high, which necessitates the search for predictors of poor outcome. An association between gene CYP2C19 alleles with lower functional activity rates cardiovascular events has been found. In a number studies, negative impact *2 *3 this polymorphic on post-infarction course was shown. However, most these studies patients were followed up from 3 months to 1 year.
 Aim: To evaluate effect polymorphism (*2, *3) long-term prognosis history ST-segment elevation (STEMI).
 Materials methods: This open-label prospective two-center study included 145 aged 45 75 years STEMI. For year STEMI on, all taking medications recommended outcome improvement, such as statins, clopidogrel component dual antiplatelet therapy, beta-blockers, angiotensin converting enzyme inhibitors. The outcomes assessed at 12 by endpoints death recurrent non-fatal MI, 5 overall MI.
 Results: During one follow up, 7 (4.8%) died causes. Recurrent MI occurred 8.3% (n = 12) patients. carriers *1*2 *1*3 genotypes 3.27-fold more likely experience within year, compared other (relative risk 3.27 [95% confidence interval 1.03; 10.36], p 0.03). After disappeared. No influence polymorphisms found (p 0.05). One hundred seven (107) years; 14 (13.0%) them died, 15 (14.0%) had MIs.
 Conclusion: responsible metabolism clopidogrel, are factors an unfavorable 12-month Subsequently, evades is not associated 5-year prognosis. improve post-STEMI it necessary implement earliest personalized approached treatment based results analysis.
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ژورنال
عنوان ژورنال: Al?manah Klini?eskoj Mediciny
سال: 2022
ISSN: ['2587-9294', '2072-0505']
DOI: https://doi.org/10.18786/2072-0505-2022-50-016