CYP2D7 Sequence Variation Interferes with TaqMan CYP2D6*15 and *35 Genotyping
نویسندگان
چکیده
منابع مشابه
CYP2D7 Sequence Variation Interferes with TaqMan CYP2D6*15 and *35 Genotyping
TaqMan™ genotyping assays are widely used to genotype CYP2D6, which encodes a major drug metabolizing enzyme. Assay design for CYP2D6 can be challenging owing to the presence of two pseudogenes, CYP2D7 and CYP2D8, structural and copy number variation and numerous single nucleotide polymorphisms (SNPs) some of which reflect the wild-type sequence of the CYP2D7 pseudogene. The aim of this study w...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2016
ISSN: 1663-9812
DOI: 10.3389/fphar.2015.00312