Cys-Loop Ligand-Gated Chloride Channels in Dorsal Unpaired Median Neurons of Locusta migratoria
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چکیده
منابع مشابه
Cys-loop ligand-gated chloride channels in dorsal unpaired median neurons of Locusta migratoria.
In insects, inhibitory neurotransmission is generally associated with members of the cys-loop ligand-gated anion channels, such as the glutamate-gated chloride channel (GluCl), the GABA-gated chloride channels (GABACl), and the histamine-gated chloride channels (HisCl). These ionotropic receptors are considered established target sites for the development of insecticides, and therefore it is ne...
متن کاملCys-loop ligand-gated chloride channels in Dorsal Unpaired Median neurons of Locusta
Daniel Janssen, Christian Derst, Jean-Michel Rigo, and Emmy Van Kerkhove 3 4 5 1 Centre of environmental sciences, Department of Physiology, Hasselt University and 6 transnationale Universiteit Limburg, Agoralaan, Diepenbeek, 3590, Belgium 7 2 Biomedical research institute, Hasselt University and transnationale Universiteit Limburg, 8 Agoralaan, Diepenbeek, 3590, Belgium 9 3 Institute for Integ...
متن کاملDorsal unpaired median neurons of locusta migratoria express ivermectin- and fipronil-sensitive glutamate-gated chloride channels.
Together with type A GABA and strychnine-sensitive glycine receptors, glutamate-gated chloride channels (GluCl) are members of the Cys-loop family of ionotropic receptors, which mediate fast inhibitory neurotransmission. To date, GluCls are found in invertebrates only and therefore represent potential specific targets for insecticides, such as ivermectin and fipronil. In this study, we identifi...
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A primary cell culture was developed for efferent dorsal unpaired median (DUM) neurons of the locust. The isolated somata were able to generate Tetrodotoxin (TTX)-sensitive action potentials in vitro. The alpha-like scorpion toxin BmK M1, from the Asian scorpion Buthus martensi Karsch, prolonged the duration of the action potential up to 50 times. To investigate the mechanism of action of BmK M...
متن کاملThe Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function.
The Cys-loop receptors constitute an important superfamily of LGICs (ligand-gated ion channels) comprising receptors for acetylcholine, 5-HT3 (5-hydroxytryptamine; 5-HT3 receptors), glycine and GABA (gamma-aminobutyric acid; GABAA receptors). A vast knowledge of the structure of the Cys-loop superfamily and its impact on channel function have been accrued over the last few years, leading to exc...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2010
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00466.2009