Cytogenetic Effects of Combined Ochratoxin A and Endosulfan in Rats
نویسندگان
چکیده
منابع مشابه
Ochratoxin a causes DNA damage and cytogenetic effects but no DNA adducts in rats.
Ochratoxin A (OTA) is a potent nephrotoxin and renal carcinogen in rats, but the mechanism of OTA tumorigenicity is unknown. Ochratoxin A has been shown to be negative in many genetic toxicology test in vitro. However, the potential of OTA to induce genotoxic effects has not been investigated in male rats, the most sensitive species for OTA-induced tumor formation. In this study, male F344 rats...
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Abbreviations: OTA: Ochratoxin-A; hr: Hour; ppm: Parts-Per Million; b.wt.: Body Weight; RBC: Red Blood Cell; Hb: Hemoglobin; PCV: Packed Cell Volume; TLC: Total Leukocyte Count; DLC: Differential Leukocyte Count; MCV: Mean Corpuscular Volume; MCH: Mean Corpuscular Hemoglobin; MCHC: Mean Corpuscular Hemoglobin Concentration; BUN: Blood Urea Nitrogen; ALP: Alkaline Phosphatase; ALT: Alanine Trans...
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ژورنال
عنوان ژورنال: Journal of Environmental & Analytical Toxicology
سال: 2014
ISSN: 2161-0525
DOI: 10.4172/2161-0525.1000217