Cytoskeleton–membrane interactions in membrane raft structure
نویسندگان
چکیده
منابع مشابه
Toward understanding the dynamics of membrane-raft-based molecular interactions.
The cell membrane is a 2-dimensional non-ideal liquid containing dynamic structures on various time-space scales, and the raft domain is one of them. Existing literature supports the concept that raft dynamics may be important for its formation and function: the raft function may be supported by stimulation-induced raft association/coalescence and recruitment of various raftophilic molecules to...
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Domains in cell membranes are created by lipid-lipid interactions and are referred to as membrane rafts. Reliable isolation methods have been developed which have shown that rafts from the same membranes have different proteins and can be sub-fractionated by immunoaffinity methods. Analysis of these raft subfractions shows that they are also comprised of different molecular species of lipids. T...
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The dynamic lateral segregation of signaling proteins into microdomains is proposed to facilitate signal transduction, but the constraints on microdomain size, mobility, and diffusion that might realize this function are undefined. Here we interrogate a stochastic spatial model of the plasma membrane to determine how microdomains affect protein dynamics. Taking lipid rafts as representative mic...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2009
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-009-0022-6