Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides
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چکیده
منابع مشابه
Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides.
Guanine-rich oligonucleotides (GROs) have attracted considerable attention as anticancer agents, because they exhibit cancer-selective antiproliferative activity and can form G-quadruplex structures with higher nuclease resistance and cellular uptake. Recently, a GRO, AS1411 has reached phase II clinical trials for acute myeloid leukemia and renal cell carcinoma. The antiproliferative activity ...
متن کاملCytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides† †Electronic supplementary information (ESI) available: Experimental details and supplementary figures. See DOI: 10.1039/c4sc03949a
Nan Zhang1,2, Tao Bing1, Xiangjun Liu1, Cui Qi1, Luyao Shen1,2, Linlin Wang1, & Dihua Shangguan1* 1 Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, china. 2 University of the Chinese Academy of Sciences, Beijing 100049, China * Corresponding Author: Tel&FAX:86-...
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2015
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c4sc03949a