D-Aspartate Regulates Melanocortin Formation and Function: Behavioral Alterations in D-Aspartate Oxidase-Deficient Mice
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منابع مشابه
D-aspartate regulates melanocortin formation and function: behavioral alterations in D-aspartate oxidase-deficient mice.
D-aspartate, an abundant D-amino acid enriched in neuroendocrine tissues, can be degraded by D-aspartate oxidase (Ddo). To elucidate the function of D-aspartate, we generated mice with targeted deletion of Ddo (Ddo(-/-)) and observe massive but selective augmentations of D-aspartate in various tissues. The pituitary intermediate lobe, normally devoid of D-aspartate from endogenous Ddo expressio...
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D-aspartic acid is abundant in the developing brain. We have identified and cloned mammalian aspartate racemase (DR), which converts L-aspartate to D-aspartate and colocalizes with D-aspartate in the brain and neuroendocrine tissues. Depletion of DR by retrovirus-mediated expression of short-hairpin RNA in newborn neurons of the adult hippocampus elicits profound defects in the dendritic develo...
متن کاملehavioural alterations in male mice lacking the gene for d-aspartate oxidase
ehavioural alterations in male mice lacking the gene for d-aspartate oxidase Zachary M. Weil a,∗,1, Alex S. Huang b,1, Anne Beigneux e, Paul M. Kim b, Mark E. Molliver b, Seth Blackshaw c, Stephen G. Young e, Randy J. Nelson a, Solomon H. Snyder b,c,d a Departments of Psychology and Neuroscience, Institute for Behavioral Medicine Research, 1835 Neil Avenue Mall, Ohio State University, Columbus,...
متن کاملBehavioural alterations in male mice lacking the gene for D-aspartate oxidase.
D-serine and D-aspartate are important regulators of mammalian physiology. D-aspartate is found in nervous and endocrine tissue, specifically in hypothalamic supraoptic and paraventricular nuclei, pituitary, and adrenal medullary cells. Endogenous D-aspartate is selectively degraded by D-aspartate oxidase. We previously reported that adult male mice lacking the gene for D-aspartate oxidase (Ddo...
متن کاملBiological role of D-amino acid oxidase and D-aspartate oxidase. Effects of D-amino acids.
D-Amino acids administered to animals are absorbed by the intestine and transported through the blood-stream to solid tissues where they are oxidized in vivo by D-amino acid oxidase and D-aspartate oxidase to produce the same compounds they do in vitro; i.e. NH3, H2O2, and the keto acid corresponding to the amino acid ingested. In the liver and kidneys of the animals, an inverse relationship ex...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2006
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.5060-05.2006