Dapsone induced cholangitis as a part of dapsone syndrome: a case report

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Dapsone induced cholangitis as a part of dapsone syndrome: a case report

BACKGROUND Dapsone can rarely cause a hypersensitivity reaction called dapsone syndrome, consisting of fever, hepatitis, exfoliative dermatitis, lymphadenopathy and hemolytic anemia. Dapsone syndrome is a manifestation of the DRESS (drug rash with eosinophilia and systemic symptoms) syndrome which is a serious condition that has been reported in association with various drugs. Cholangitis in da...

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Dapsone syndrome--first Malaysian paediatric case report.

Dapsone syndrome is a potentially fatal hypersensitivity reaction to sulphone. We report a 12-year-old girl who developed high grade fever associated with intense jaundice, exfoliative skin rash and hepatomegaly after five weeks of starting the multidrug regimen for the treatment of Hansen's disease. Laboratory investigations revealed presence of leucocytosis with eosinophilia, deranged liver e...

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Acne fulminans with dapsone induced haemolysis: a case report.

124 was seen at the Dermatology Clinic, University Hospital, Kuala Lumpur. Physical examination showed a healthy young female with severe pustular acne on her forehead and cheeks (Fig. 1l. There was no fever or arthralgia. Due to her poor response to the oral tetracycline prescribed previously by her doctor, she was started on oral dapsone 1OO/mg dai ly and advised to wash her face with 1% cetr...

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CASE REPORT Dapsone hypersensitivity syndrome in a lepromatous leprosy patient – A Case Report

Dapsone hypersensitivity syndrome (DHS) can be classified as a ‘drug reaction with eosinophilia and systemic symptoms’ (DRESS). It has a variable course, it is not dose dependent and may present with different clinical and laboratory abnormalities. In some cases it may be fatal. We describe a 31 year old man with lepromatous leprosy in whom DHS developed 4 weeks after initiation of World Health...

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Severe dapsone hypersensitivity syndrome.

Dapsone, a potent antiparasitic and anti-inflammatory compound, is mainly used in the treatment of leprosy and a variety of blistering skin diseases. It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome. We report the case of a 21-year-old female patient with dapsone hypersensitivity syndrome. The clinical presentation mimicked a vir...

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ژورنال

عنوان ژورنال: BMC Gastroenterology

سال: 2003

ISSN: 1471-230X

DOI: 10.1186/1471-230x-3-21