Deamidation in Moxetumomab Pasudotox Leading to Conformational Change and Immunotoxin Activity Loss
نویسندگان
چکیده
منابع مشابه
Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox.
Recombinant immunotoxins are fusion proteins that contain the cytotoxic portion of a protein toxin fused to the Fv portion of an antibody. The Fv binds to an antigen on a target cell and brings the toxin into the cell interior, where it arrests protein synthesis and initiates the apoptotic cascade. Moxetumomab pasudotox, previously called HA22 or CAT-8015, is a recombinant immunotoxin composed ...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Sciences
سال: 2020
ISSN: 0022-3549
DOI: 10.1016/j.xphs.2020.06.002