DeepSurv: personalized treatment recommender system using a Cox proportional hazards deep neural network
نویسندگان
چکیده
منابع مشابه
DeepSurv: personalized treatment recommender system using a Cox proportional hazards deep neural network
BACKGROUND Medical practitioners use survival models to explore and understand the relationships between patients' covariates (e.g. clinical and genetic features) and the effectiveness of various treatment options. Standard survival models like the linear Cox proportional hazards model require extensive feature engineering or prior medical knowledge to model treatment interaction at an individu...
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MOTIVATION There has been an increasing interest in expressing a survival phenotype (e.g. time to cancer recurrence or death) or its distribution in terms of a subset of the expression data of a subset of genes. Due to high dimensionality of gene expression data, however, there is a serious problem of collinearity in fitting a prediction model, e.g. Cox's proportional hazards model. To avoid th...
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Currently, for a variety of mechatronic systems and components, sufficient failure behaviour data are not available. Endurance tests at customer-specific operating conditions provide manufacturers with specific failure time data. However, they are timeconsuming and expensive. Findings gained through experiments are valid only for the applied test conditions and loads. On the other hand, develop...
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Some failure time data come from a population that consists of some subjects who are susceptible to and others who are nonsusceptible to the event of interest. The data typically have heavy censoring at the end of the follow-up period, and a standard survival analysis would not always be appropriate. In such situations where there is good scientific or empirical evidence of a nonsusceptible pop...
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The Cox proportional hazards regression model has been widely used in the analysis of survival/duration data. It is semiparametric because the model includes a baseline hazard function that is completely unspecified. We study here the statistical inference of the Cox model where some information about the baseline hazard function is available, but it still remains as an infinite dimensional nui...
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ژورنال
عنوان ژورنال: BMC Medical Research Methodology
سال: 2018
ISSN: 1471-2288
DOI: 10.1186/s12874-018-0482-1