Defining Early Multidisciplinary Goals: NEXTO Trial in High-Risk Colorectal Cancer with Liver Metastases

Multidisciplinary approach of colorectal cancer liver metastases

Large bowel cancer is a worldwide public health challenge. More than one third of patients present an advanced stage of disease at diagnosis and the liver is the most common site of metastases. Selection criteria for early diagnosis, chemotherapy and surgery have been recently expanded. The definition of resectability remains unclear. The presence of metastases is the most significant prognosti...

Colorectal cancer with synchronous liver metastases.

Managing colorectal cancer liver metastases.

The treatment of resectable colorectal cancer metastases to the liver has undergone changes with the addition of active chemotherapeutic agents, innovations and definition in the surgical procedures, understanding of the benefits and toxicities of the surgical and chemotherapeutic (cytotoxic and biologic) interventions, and use of the team approach. Patients are initially evaluated for the over...

Update and review of the multidisciplinary management of stage IV colorectal cancer with liver metastases

BACKGROUND The management of stage IV colorectal cancer with liver metastases has historically involved a multidisciplinary approach. In the last several decades, there have been great strides made in the therapeutic options available to treat these patients with advancements in medical, surgical, locoregional and adjunctive therapies available to patients with colorectal liver metastases(CLM)....

Multidisciplinary Symposium — Liver Metastases

Patients with hepatic metastases from colorectal cancer have a poor prognosis, with a median survival of less than 12 months. Although chemotherapy may have a beneficial effect on the natural history of unresected liver metastases, 5-year survival is difficult to achieve by chemotherapy alone. Hepatic resection can achieve prolonged survival with an acceptable mortality risk in selected patient...