Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor
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چکیده
منابع مشابه
Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor.
Endothelial cells in most vascular beds release a factor that hyperpolarizes the underlying smooth muscle, produces vasodilatation, and plays a fundamental role in the regulation of local blood flow and systemic blood pressure. The identity of this endothelium-derived hyperpolarizing factor (EDHF), which is neither NO nor prostacyclin, remains obscure. Herein, we demonstrate that in mesenteric ...
متن کاملNatriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide.
BACKGROUND Ischemia/reperfusion (I/R) injury complicates myocardial infarction and stroke by exacerbating tissue damage and increasing risk of mortality. We have recently identified C-type natriuretic peptide (CNP) as an endothelium-derived hyperpolarizing factor in the mesenteric resistance vasculature and described a novel signaling pathway involving activation of natriuretic peptide receptor...
متن کاملEndothelium-Derived C-Type Natriuretic Peptide Myocardial Ischemia/Reperfusion Injury: Novel Cardioprotective Role for Natriuretic Peptide Receptor-C Regulates Coronary Blood Flow and Prevents
Copyright © 2004 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online 72514 Circulation is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX DOI: 10.1161/01.CIR.0000141802.29945.34 2004;110;1231-1235; originally published online Aug 30, 2004; Circulation Adrian Hobbs, Paul Foster, Craig Prescott, Ramona Scotland and Amrita Ahluwalia Endoth...
متن کاملUrinary C-Type Natriuretic Peptide
Cardiorenal Research La , Rochester, Minnesota; a innesota. This work was O1 HL36634 and PO1 H tional Research (grant no lingham, Ms. Heublein, D the use of urinary C-type hey have no relationships pt received November 13 cepted December 5, 2012 his study was conducted to determine whether urinary excretion of C-type natriuretic peptide (CNP) is elevated in acute decompensated heart failure (AD...
متن کاملThe role of C-type natriuretic peptide in cardiovascular medicine.
0195-668X/01/120997+11 $35.00/0 conventional drug therapy, in order to reduce plasma aminoterminal BNP levels, resulted in reduced total cardiovascular events when compared to therapy directed by clinical acumen. Much less is known about C-type natriuretic peptide (CNP) which was first isolated from porcine brain in 1990. It is now known that CNP has a much wider distribution and of particular ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2007
ISSN: 0008-6363
DOI: 10.1016/j.cardiores.2007.02.032