Degranulation and Histamine Release in Focal Antigen-Antibody Reaction by Means of Microelectrophoresis in a Single Rat Mesentery Mast Cell1
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چکیده
منابع مشابه
Selective release of histamine from rat mast cells by compound 48/80 and antigen
JOHNSON, ALICE R., AND NEIL C. MORAN. Selective release of histamine from rat mast cells by compound 48/80 and antigen. Am. J. Physiol. 216(3) : 453-459. 1969.-To test the hypothesis that rat mast cells are not disrupted by the action of histamine-releasing agents such as compound 48/80 and antigen, suspensions of mast cells were treated with these agents and the release of histamine and other ...
متن کاملMast Cell Degranulation and Histamine Release Observed in a New in Vitro System
A method is described by which mast cells harvested from the rat peritoneal cavity can be deposited on the surface of a Millipore filter without gross injury, permitting observation of morphological and chemical changes induced by a variety of agents. These isolated peritoneal mast cells respond to 48/80 and to polymyxin B but not to dextran or ovomucoid with degranulation and histamine release...
متن کاملRecovery of purification-associated reduction in antigen-induced histamine release from rat peritoneal mast cells.
Immunoglobulin E (IgE)-dependent histamine release from purified rat peritoneal mast cells (PMC) is very low in comparison to that from a non-purified preparation (PEC). The reduced histamine release from PMC is recovered or potentiated by reconstitution with separated non-mast cells (NMC). In the present study, further characterization was undertaken to elucidate the mechanisms involved. Sensi...
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15 صفحه اولAzelastine and '5Ca uptake Antiallergic agent, azelastine, inhibits 45Ca uptake and histamine release in rat mast cells stimulated by antigen
The effect of antiallergic agent, azelastine, was examined in immunogical secretory process of mast cells. 1. Azelastine significantly inhibited '"Ca uptake by mast cells stimulated by antigen, and the maximum inhibition was attained at a concentration of 50 11 11/me showing approximately 30.5 % inhibition. 2. Azelastine also inhibite the release of histamine from mast cells by antigen. The max...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1972
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)31711-1