DEL-1-Regulated Immune Plasticity and Inflammatory Disorders

Cytokine-Regulated Eosinophil Migration in Inflammatory Disorders

Lampinen, M. 2000.Cytokine-regulated eosinophil migration in inflammatory disorders. Clinical and experimental studies. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 971. 60 pp. Uppsala. ISBN 91-554-4849-6. The accumulation of eosinophil granulocytes (EOS) at sites of inflammation is a common feature of asthma, allergic rhinitis an...

Complement in immune and inflammatory disorders: pathophysiological mechanisms.

Although acute or chronic inflammation is a common component of many clinical disorders, the underlying processes can be highly distinct. In recent years, the complement system has been associated with a growing number of immunological and inflammatory conditions that include degenerative diseases, cancer, and transplant rejection. It becomes evident that excessive activation or insufficient co...

Complement in immune and inflammatory disorders: therapeutic interventions.

With the awareness that immune-inflammatory cross-talk is at the heart of many disorders, the desire for novel immunomodulatory strategies in the therapy of such diseases has grown dramatically. As a prime initiator and important modulator of immunological and inflammatory processes, the complement system has emerged as an attractive target for early and upstream intervention in inflammatory di...

Disorders: Pathophysiological Mechanisms Complement in Immune and Inflammatory

Covariance Plasticity and Regulated Criticality

We propose that a regulation mechanism based on Hebbian covariance plasticity may cause the brain to operate near criticality. We analyze the e ect of such a regulation on the dynamics of a network with excitatory and inhibitory neurons and uniform connectivity within and across the two populations. We show that, under broad conditions, the system converges to a critical state lying at the comm...