Deoxyribonucleic Acid: Structure, Synthesis and Function
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چکیده
منابع مشابه
Synthesis, Structure, and Deoxyribonucleic Acid Sequencing with a Universal Nucleoside:
A nucleoside analogue, 1 -(2’-deoxy-~-~-ribofuranosyl)-3-nitropyrrole (4) was designed to function as a universal replacement for any of the natural nucleosides in DNA sequences. Compound 4 was synthesized by the reaction of 3-nitropyrrole with sodium hydride and l-chloro-2-deoxy-3,5-di-O-toluoyl-~-e~opentofuranose, and the structure was confirmed by X-ray diffraction. Nucleoside 4 was transfor...
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Ribonucleotide reductases (EC 1 .I 7.4.1 and EC 1.17.4.2) catalyse the reduction of ribonucleoside 5’-diphosphates or triphosphates to the corresponding 2’-deoxyribonucleotides and are key enzymes for the onset of DNA replication during the cell cycle (Reichard, 1968; Follmann, 1974). The reduction of the 2’-hydroxyl group of the ribose moiety in a ribonucleotide is dependent on NADPH, but this...
متن کاملDeoxyribonucleic Acid Synthesis
Exposure of Escherichia coli cells to myxin results in the almost complete in'hibition of new deoxyribonucleic acid (DNA) synthesis, extensive degradation of pre-existing intracellular DNA, and a rapid loss of viability in these cells (9). After exposure to myxin for 30 min (<1% survivors and >25% degradation of DNA), infection of these cells by T4 bacteriophage results in the renewal of DNA sy...
متن کاملEnzymatic Synthesis of Deoxyribonucleic Acid. Deoxyribonucleic Acid By
MISSOURI The enzymatic synthesis of DNA1 in sufficient excess over the DNA used to prime the reaction21 a has enabled us to examine the chemical composition of the synthetic product. As has already been demonstrated, this DNA consists of deoxy-nucleotides Linked by typical 3'-5' phosphodiester bonds, and all four of the deoxy
متن کاملRegulation of Deoxyribonucleic Acid Synthesis
These enzymes (Grav, 1967) are responsible for the synthesis of the monomeric precursors of DNA, namely dATP, dCTP, dGTP and dTTP. Fluctuations in the activities of some of the enzymes and in the intracellular deoxyribonucleotide pools are known to occur throughout the cell cycle (Grav, 1967; Nordenskjold et al., 1970; Adams et al., 1971 ; Skoog & Nordenskjold, 1971). Moreover, there is inducti...
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ژورنال
عنوان ژورنال: Nature
سال: 1961
ISSN: 0028-0836,1476-4687
DOI: 10.1038/192024a0