Dermoscopy, Optical Coherence Tomography, and Histological Correlation of Pseudoxanthoma Elasticum

Optical coherence tomography angiography findings of choroidal neovascularization in pseudoxanthoma elasticum

Angioid streaks (AS) are the most common ocular manifestation in patients with pseudoxanthoma elasticum (PXE). The major cause of severe visual loss in patients with AS is choroidal neovascularization (CNV). We report the optical coherence tomography angiography (OCTA) findings of CNV in a patient with PXE and angioid streaks. A 51-year-old man with PXE presented with visual disturbance in his ...

Automated macular choroidal thickness measurement by swept-source optical coherence tomography in pseudoxanthoma elasticum

INTRODUCTION Pseudoxanthoma elasticum (PXE) typically involves elastic fibers in blood vessels and Bruch membrane. Our purpose was to analyze retinal and choroidal macular thickness in patients with angioid streaks due PXE compared with a control group. METHODS Best-corrected visual acuity (BCVA), axial length (AL), and macular swept-source optical coherence tomography were obtained. Automate...

Pseudoxanthoma elasticum

Pseudoxanthoma elasticum (PXE) is a genetic metabolic disease with autosomal recessive inheritance caused by mutations in the ABCC6 gene. The lack of functional ABCC6 protein leads to ectopic mineralization that is most apparent in the elastic tissues of the skin, eyes and blood vessels. The clinical prevalence of PXE has been estimated at between 1 per 100,000 and 1 per 25,000, with slight fem...

Pseudoxanthoma elasticum

Multimodal Optospectral Investigation of Melanocytic Skin Lesions: a Correlation Study Using Optical Coherence Tomography and Dermoscopy

Optical coherence tomography (OCT) is one of the best options, in terms of skin penetration depth and resolution, for skin lesion diagnosis. This study reports on the use of OCT for the in vivo imaging analysis of 67 melanocytic skin lesions in 34 patients. The OCT results have been compared with the dermoscopy – the standard non-invasive, visible-light-based skin imaging technique. The variati...