Design and Development of Dual Functional Colon Targeted Eudragit/Chitosan Nanoparticles: A QbD Approach

Abstract: Aim: The goal of this study was to develop colon-targeted nanoparticulate systems the anti-inflammatory agent Quercetin (QU) and evaluate formulation for various parameters that would allow active ingredient be released at a predetermined time location with better pharmaceutical therapeutic properties. Materials Methods: Quercetin-loaded chitosan nanoparticles were formulated purpose using ionic gelation method by employing Central Composite Design. To coat Eudragit S 100 (ES 100) on an optimised quercetin loaded (QLCN), oil in solvent evaporation process used. Particle size (PS), polydispersity index (PDI), scanning electron microscopy (SEM), drug release (% DR) evaluated characterize nanoparticles. Results: has average PS 114.2 ± 1.42 nm 0.396 0.02, whereas coated shows 330.2± 0.40 0.412 0.02. Surface morphology prepared confirmed SEM. According vitro analysis nanostructured formulations, ES coating QLCN inhibits upper gastrointestinal system, demonstrating good colon targeting. Conclusion: nanoparticle limits effective Keywords: Anti-inflammatory agent, Ionic method, composite design, nanoparticles, 100, Colon