DESIGN AND IN VITRO EVALUATION STUDIES OF DICLOFENAC SODIUM FLOATING MATRIX TABLETS BY MELT GRANULATION TECHNIQUE
نویسندگان
چکیده
منابع مشابه
Formulation and Evaluation of Diclofenac Sodium Sustained Release Tablets Using Melt Granulation Technique
Hydrophilic polymers alone are not quite efficient in controlling the release of highly water soluble drugs. Hydrophobic Polymer and pore forming agent have been extensively investigated for sustaining the release of drug. They provide several advantages include good stability at varying pH ranges and effectively retards the water soluble drug. In the present study it was a novel approach where...
متن کاملDesign and Evaluation of Xanthan Gum-based Sustained Release Matrix Tablets of Diclofenac Sodium
In the present investigation, an attempt has been made to increase therapeutic efficacy, reduce frequency of administration, and improve patient compliance, by developing sustained release matrix tablets of diclofenac sodium. Sustained release matrix tablets of diclofenac sodium, were developed by using different drug: polymer ratios, such as F1 (1:0.12), F2 (1:0.16), F3 (1:0.20), F4 (1:0.24) a...
متن کاملDesign and Optimization of Novel Sugar Alcohol Based Extended Release Tablets Prepared by Melt Dispersion Technique
The aim of this study is to prepare novel sorbitol based extended release tablets by melt dispersion method using carbamazepine as a model drug. Carbamazepine was melted along with sugar alcohol to get melt dispersion granules (MGDs) and was characterized by differential scanning calorimetry (DSC), powder X-ray diffractometry (XRD) and solubility study. The physical and chemical parameters...
متن کاملStudies on Formulation and In Vitro Evaluation of Floating Matrix Tablets of Domperidone
Floating matrix tablets of domperidone were developed to prolong gastric residence time and thereby increased drug bioavailability. Domperidone was chosen as a model drug because it is poorly absorbed from the lower gastrointestinal tract. The tablets were prepared by wet granulation technique, using polymers such as hydroxypropylmethylcellulose K4M, carbopol 934P, and sodium alginate, either a...
متن کاملFormulation Optimization and In-vitro Evaluation of Oral Floating Captopril Matrix Tablets using Factorial Design
Purpose: To develop a zero-order sustained release floating formulation of captopril, and optimize its drug release for enhanced oral bioavailability. Methods: A relatively new approach, 3 full factorial design, was used to formulate floating captopril matrix tablets and to systematically optimize its drug release using varying levels of xanthan gum and hydroxypropyl methylcellulose (HPMC) K100...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Research Journal of Pharmacy
سال: 2013
ISSN: 2230-8407
DOI: 10.7897/2230-8407.04531