Design and optimization of floating drug delivery system of acyclovir
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چکیده
منابع مشابه
Design and Optimization of Floating Drug Delivery System of Acyclovir
The purpose of the present work was to design and optimize floating drug delivery systems of acyclovir using psyllium husk and hydroxypropylmethylcellulose K4M as the polymers and sodium bicarbonate as a gas generating agent. The tablets were prepared by wet granulation method. A 3(2) full factorial design was used for optimization of drug release profile. The amount of psyllium husk (X1) and h...
متن کاملFloating Drug Delivery System
The aim of writing this review on gastro retentive and floating drug delivery system was to compile the new literature with the principle mechanism of floatation to acquired gastric retention. Various attempts have been made to develop gastroretentive delivery systems such as high density system, swelling, floating system. In floating multiple unit and single unit system are design and their cl...
متن کاملDevelopment and evaluation of a monolithic floating drug delivery system for acyclovir.
Acyclovir (ACV), a model drug for this study, is one of the most effective drugs against viruses of the herpes group. Absorption of orally administered ACV is variable and incomplete, with a bioavailability of ca. 15-30%. The drug is absorbed in the duodenum after oral administration and hence, preparation of a floating drug delivery system (FDDS) for ACV may increase oral absorption of the dru...
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15 صفحه اولFormulation and Optimization of Mucoadhesive Nanodrug Delivery System of Acyclovir
Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infections, with an oral bioavailability of only 10-20% [limiting absorption in gastrointestinal tract to duodenum and jejunum] and half-life of about 3 h, and is soluble only at acidic pH (pKa 2.27). Mucoadhesive polymeric nanodrug delivery systems of acyclovir have been designed and optimized using 2(3) full factori...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2010
ISSN: 0250-474X
DOI: 10.4103/0250-474x.78527