Design & Characterization of Tolcapone Floating Microspheres
نویسندگان
چکیده
منابع مشابه
Preparation and In-vitro Characterization of Floating Microspheres of Nateglinide
Gastric residence time of oral controlled release system such as microspheres is increase by different techniques such as floating and mucoadhesive system. The objective of present investigation was to formulate floating microspheres of Nateglinide in order to increase gastric residence time, increased bioavailability and to reduce dose frequency of drug molecule. Novel o/w emulsion solvent dif...
متن کاملFloating microspheres of cimetidine: formulation, characterization and in vitro evaluation.
The present study involves preparation and evaluation of floating microspheres with cimetidine as model drug for prolongation of gastric residence time. The microspheres were prepared by the solvent evaporation method using polymers hydroxypropylmethyl cellulose and ethyl cellulose. The shape and surface morphology of prepared microspheres were characterized by optical and scanning electron mic...
متن کاملDesign and Characterization of Cisplatin Magnetic Microspheres
The present study is aimed at the overall improvement in the efficacy, reduction in toxicity and enhancement of therapeutic index of cisplatin. Magnetically responsive biodegradable microparticulate delivery system of cisplatin has been developed by phase separation emulsion polymerization technique by using bovine serum albumin. The formulations were evaluated with respect to particle size ana...
متن کاملFloating microspheres encapsulating carvedilol for the effective management of hypertension
Carvedilol (CVD) is an antihypertensive agent with a short half-life, pH-dependent solubility, and narrow absorption window. The purpose of this research was to prepare a floating-drug delivery-system of carvedilol to increase its half-life. The present study investigates the preparation of carvedilol-floating microspheres, evaluates the floating-drug delivery-system (FDDS) (by scanning electro...
متن کاملImproved bioavailability through floating microspheres of lovastatin
BACKGROUND AND THE PURPOSE OF THE STUDY Lovastatin is an antihyperlipidemic agent which has low bioavailability due to the extensive first pass metabolism. It was sought to increase gastric retention of lovastatin by development of a sustained release gastroretentive drug delivery system leading to reduced fluctuation in the plasma concentration and improved bioavailability. MEHODS: Floating m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of PharmTech Research
سال: 2018
ISSN: 2249-3387
DOI: 10.46624/ajptr.2018.v8.i2.012