DESIGN, DEVELOPMENT AND OPTIMIZATION OF MOUTH DISSOLVING TABLET OF AMBRISENTAN USING DESIGN EXPERT SOFTWARE

Objective: The rationale of the current work is to design, develop and optimize mouth dissolving tablet ambrisentan treat hypertension. Methods: Sodium starch glycolate crospovidone were used as super disintegrants in direct compression method create nine mouth-dissolving formulations. Wetting time, drug content, vitro disintegration dispersion dissolution time all assessed for produced Results: Based on results obtained, formulation F6 containing 30 mg exhibited good wetting release. hardness formulations AS1 AS9 was found be range 2.5 3.11 Kg/cm2. friability less than 1%. A water absorption ratio performed ensuring moisture sorption uptake properties disintegrants. release AS6 a concentration Crospovidone mg, shows 91.30% respectively at end 12 min. Conclusion: tablets successfully designed, developed, fabricated. It can reasonably concluded that batch with maximum cumulative