Design of a transdermal formulation containing raloxifene nanoparticles for osteoporosis treatment

investigating the feasibility of a proposed model for geometric design of deployable arch structures

deployable scissor type structures are composed of the so-called scissor-like elements (sles), which are connected to each other at an intermediate point through a pivotal connection and allow them to be folded into a compact bundle for storage or transport. several sles are connected to each other in order to form units with regular polygonal plan views. the sides and radii of the polygons are...

Osteoporosis treatment: raloxifene (Evista) and stroke mortality.

Drug Evaluation Raloxifene for the treatment of postmenopausal osteoporosis

Estrogen is a potent inhibitor of osteoclastic bone resorption. After menopause, osteoclastic resorption is accelerated due to the decrease in endogenous estradiol levels. Hormone replacement can prevent bone loss and reduce risk of fractures [1–3]. However, use of estradiol and conjugated estrogens alone (estrogen therapy [ET]) or combined with progestins (estrogen progestin therapy [EPT]) may...

Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application

Raloxifene hydrochloride, a highly effective drug for the treatment of invasive breast cancer and osteoporosis in post-menopausal women, shows poor oral bioavailability of 2%. The aim of this study was to develop, statistically optimize, and characterize raloxifene hydrochloride-loaded transfersomes for transdermal delivery, in order to overcome the poor bioavailability issue with the drug. A r...

Hydrogels containing redispersible spray-dried melatonin-loaded nanocapsules: a formulation for transdermal-controlled delivery

The aim of the present study was to develop a transdermal system for controlled delivery of melatonin combining three strategies: nanoencapsulation of melatonin, drying of melatonin-loaded nanocapsules, and incorporation of nanocapsules in a hydrophilic gel. Nanocapsules were prepared by interfacial deposition of the polymer and were spray-dried using water-soluble excipients. In vitro drug rel...