Designing an extracellular matrix protein with enhanced mechanical stability
نویسندگان
چکیده
منابع مشابه
Designing an extracellular matrix protein with enhanced mechanical stability.
The extracellular matrix proteins tenascin and fibronectin experience significant mechanical forces in vivo. Both contain a number of tandem repeating homologous fibronectin type III (fnIII) domains, and atomic force microscopy experiments have demonstrated that the mechanical strength of these domains can vary significantly. Previous work has shown that mutations in the core of an fnIII domain...
متن کاملMechanical interaction of angiogenic microvessels with the extracellular matrix.
Angiogenesis is the process by which new blood vessels sprout from existing blood vessels, enabling new vascular elements to be added to an existing vasculature. This review discusses our investigations into the role of cell-matrix mechanics in the mechanical regulation of angiogenesis. The experimental aspects of the research are based on in vitro experiments using an organ culture model of sp...
متن کاملCorrection: Ca2+ Binding Enhanced Mechanical Stability of an Archaeal Crystallin
Structural topology plays an important role in protein mechanical stability. Proteins with β-sandwich topology consisting of Greek key structural motifs, for example, I27 of muscle titin and (10)FNIII of fibronectin, are mechanically resistant as shown by single-molecule force spectroscopy (SMFS). In proteins with β-sandwich topology, if the terminal strands are directly connected by backbone H...
متن کاملAn Effective Strategy for the Design of Proteins with Enhanced Mechanical Stability**
There is increasing interest in the investigation of so-called mechanical proteins. These are common in specialized tissues involved in contraction, cell adhesion, and detection of mechanical stimuli, such as skeletal and cardiac striated muscle, connective tissue, and various kinds of epithelia. The development of methods for manipulating single molecules, particularly atomic force microscopy ...
متن کاملSoy Protein/Cellulose Nanofiber Scaffolds Mimicking Skin Extracellular Matrix for Enhanced Wound Healing.
Historically, soy protein and extracts have been used extensively in foods due to their high protein and mineral content. More recently, soy protein has received attention for a variety of its potential health benefits, including enhanced skin regeneration. It has been reported that soy protein possesses bioactive molecules similar to extracellular matrix (ECM) proteins and estrogen. In wound h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2007
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0609901104