Detecting Somatic Mutations in Normal Cells
نویسندگان
چکیده
منابع مشابه
Extensive somatic microsatellite mutations in normal human tissue.
Microsatellite (MS) instability occurs in tumors with DNA mismatch repair (MMR) deficiencies but is typically absent in adjacent normal tissue. However, MS mutations have been observed in normal tissues from rare individuals with congenital MMR deficiencies. Autopsy tissues from a 4-year-old with congenital MMR deficiency (MLH1-/-) were examined for MS mutations. Insertions and deletions were o...
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In attempts to find a prescreen for mutagens that may induce heritable mutations in mammals, an in vivo somatic mutation test has been developed in the mouse that uses a localized gene product (hair pigment), is relatively fast and cheap, and gives results that have some predictive value for point mutation induction in spermatogonia. Embryos heterozygous at specific coat color loci are exposed ...
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The transformation of a normal cell into a cancer cell takes place through a sequence of a small number of discrete genetic events, somatic mutations: thus, cancer can be regarded properly as a genetic disease of somatic cells. The analogy between evolution of organisms and evolution of cell populations is compelling: in both cases what drives change is mutation, but it is Darwinian selection t...
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The Kolmogorov-Arnold stochasticity parameter technique is applied for the first time to the study of cancer genome sequencing, to reveal mutations. Using data generated by next-generation sequencing technologies, we have analysed the exome sequences of brain tumour patients with matched tumour and normal blood. We show that mutations contained in sequencing data can be revealed using this tech...
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ژورنال
عنوان ژورنال: Trends in Genetics
سال: 2018
ISSN: 0168-9525
DOI: 10.1016/j.tig.2018.04.003