Detection of hepatitis C virus sequences in brain tissue obtained in recurrent hepatitis C after liver transplantation
نویسندگان
چکیده
منابع مشابه
Hepatitis C virus recurrence after liver transplantation.
Cirrhosis due to hepatitis C virus (HCV) is now the most common indication of liver transplantation in Western Europe and the United States. In the absence of effective prophylaxis, recurrent HCV infection is almost inevitable. Though the natural history and intermediate term outcome of recurrent HCV are now better documented, those factors which may influence the recurrence of hepatitis and co...
متن کاملGenetic clustering of hepatitis C virus strains and severity of recurrent hepatitis after liver transplantation.
The influence of viral factors on the severity of hepatitis C virus (HCV)-related liver disease is controversial. We studied 68 liver transplant patients with recurrent hepatitis C, of whom 53 were infected by genotype 1 strains. Relationships between core sequences, serum HCV RNA levels, and fibrosis scores for each patient were analyzed in pairwise fashion 5 years after transplantation. We us...
متن کاملManagement of recurrent hepatitis C after liver transplantation.
Hepatitis C virus (HCV) reinfection is almost universal in patients transplanted for HCV-related cirrhosis. The medium-term survival after orthotopic liver transplantation (OLT) is similar to other transplanted patients, but the long-term survival remains uncertain. The prevention and an effective treatment of progressive liver disease are the primary aims in HCV recurrence. Interferon and riba...
متن کاملKinetics of hepatitis C virus reinfection after liver transplantation.
Improved understanding of hepatitis C virus (HCV) dynamics during and after liver transplantation can be useful in optimizing antiviral therapy in transplant recipients. We analyzed serum HCV ribonucleic acid (RNA) levels during and after cadaveric liver transplantation in 6 HCV patients. After removal of the liver and before the new liver started producing virions, HCV RNA levels dropped with ...
متن کاملRecurrence of hepatitis C after liver transplantation
Recurrence of hepatitis C virus (HCV) infection following liver transplantation is a major source of morbidity and mortality. The natural history of hepatitis C in the transplant setting is shortened. Overall, one third of HCV-infected recipients have developed allograft cirrhosis due to HCV recurrence by the 5th-7th year post-transplantation. The most significant variables which determine dise...
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ژورنال
عنوان ژورنال: Liver Transplantation
سال: 2002
ISSN: 1527-6465
DOI: 10.1053/jlts.2002.36393