Detection of Placental Transcription Factor mRNA in Maternal Plasma
نویسندگان
چکیده
منابع مشابه
Detection of placental transcription factor mRNA in maternal plasma.
mRNA of placental origin, including chromosome 21encoded mRNA, can be detected reliably in maternal plasma during the first trimester of pregnancy (1, 2). The presence and detectability of placental RNA in maternal plasma permits rapid screening of new markers to test their feasibility for use in noninvasive prenatal diagnostic assays. In contrast to conventional protein-based assays, new marke...
متن کاملDetection of chromosome 21-encoded mRNA of placental origin in maternal plasma.
BACKGROUND mRNA of placental origin (i.e., human placental lactogen and beta-human chorionic gonadotropin) has been demonstrated to be easily detectable in maternal plasma. We tested whether detection of chromosome 21-encoded mRNA of placental origin is possible in maternal plasma obtained during the first trimester. METHODS Plasma samples were obtained from pregnant women between weeks 9-13 ...
متن کاملDetection and characterization of placental microRNAs in maternal plasma.
BACKGROUND The discovery of circulating fetal nucleic acids in maternal plasma has opened up new possibilities for noninvasive prenatal diagnosis. MicroRNAs (miRNAs), a class of small RNAs, have been intensely investigated recently because of their important regulatory role in gene expression. Because nucleic acids of placental origin are released into maternal plasma, we hypothesized that miRN...
متن کاملDetection of cell free placental DNA in maternal plasma: direct evidence from three cases of confined placental mosaicism.
F etal cells are consistently found in the maternal circulation, and polymerase chain reaction based studies have led to the identification of cell free fetal DNA (fetal DNA) in maternal blood. Approximately 1.2 nucleated fetal cells/ml of whole blood from women carrying a male fetus were detectable, and relative enrichment of fetal DNA was detected in the maternal plasma and serum. The amount ...
متن کاملDetection of the placental epigenetic signature of the maspin gene in maternal plasma.
The discovery of fetal DNA in the plasma of pregnant women has opened up new approaches for noninvasive prenatal diagnosis and monitoring. Up to now, the lack of a fetal DNA marker that can be universally detected in maternal plasma has limited the clinical application of this technology. We hypothesized that epigenetic differences between the placenta and maternal blood cells could be used for...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2004
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2004.032979