Determinants of antiarrhythmic drug efficacy for ventricular tachyarrhythmias using ambulatory monitoring and electrophysiological techniques.

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Determinants of antiarrhythmic drug efficacy for ventricular tachyarrhythmias using ambulatory monitoring and electrophysiological techniques.

Sustained ventricular tachycardia and ventricular fibrillation are life-threatening arrhythmias with high rates of recurrence.1'2 Empiric antiarrhythmic drug therapy has a low success rate for preventing recurrences of these arrhythmias.3 Therefore, the choice of drug therapy has centered around two methodologies to predict drug efficacy: programmed ventricular stimulation with serial drug test...

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Efficacy for Ventricular Tachyarrhythmias Using Ambulatory Monitoring and Electrophysiological Techniques

Sustained ventricular tachycardia and ventricular fibrillation are life-threatening arrhythmias with high rates of recurrence.1'2 Empiric antiarrhythmic drug therapy has a low success rate for preventing recurrences of these arrhythmias.3 Therefore, the choice of drug therapy has centered around two methodologies to predict drug efficacy: programmed ventricular stimulation with serial drug test...

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Antiarrhythmic and arrhythmogenic action of inosine in experimental ventricular tachyarrhythmias.

OBJECTIVE To study the possible action of inosine on experimental ventricular tachyarrhythmias. MATERIAL AND METHODS We used 92 mongrel dogs weighing 13 kg-17 kg, anesthetized with 30 mg/kg sodium pentobarbital applied intravenously. Myocardial lesions were induced by injecting 1 ml-1.5 ml of 70% phenol in the free wall of the left ventricle. In 36 dogs, the ventricular arrhythmia (VT) was in...

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Suppression of sustained ventricular tachyarrhythmias: a comparison of d,l-sotalol with no antiarrhythmic drug treatment.

OBJECTIVES This study evaluates the clinical efficacy of d,l-sotalol in patients with sustained ventricular tachyarrhythmias. BACKGROUND D,l-sotalol is an important antiarrhythmic agent to prevent recurrences of sustained ventricular tachyarrhythmias (VT/VF). However, evidence is lacking that an antiarrhythmic agent like d,l-sotalol can reduce the incidence of sustained ventricular tachyarrhy...

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Antiarrhythmic Therapy for Atrial Tachyarrhythmias

Antiarrhythmic therapy can have a key role in prolonging the lives of patients with most common atrial tachyarrhythmias such as atrial flutter (AFL) or atrial fibrillation (AF). The optimal use of antiarrhytmic drug therapy depends in part on understanding the underlying mechanisms of AFL and AF and pharmacodynamis of each antiarrhythmic drug. Currently, there is a large body of experimental an...

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ژورنال

عنوان ژورنال: Circulation

سال: 1993

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.87.2.643