Developing and maintaining a sound undergraduate clerkship curriculum [published erratum appears in Acad Med 1990 Oct;65(10):629]
نویسندگان
چکیده
منابع مشابه
A shared idiotype among human anti-Ro/SSA autoantibodies [published erratum appears in J Exp Med 1990 Feb 1;171(2):591]
Idiotypes and antiidiotypes are thought to be important immune regulators and have provided clues for the origin and pathogenicity of autoantibodies. Many lupus and Sjögren's syndrome patients, as well as most neonatal lupus infants with congenital heart block or dermatitis, have antibodies to the ribonucleoprotein Ro/SSA, which is one of a group of RNA-protein autoantigens commonly found in hu...
متن کاملPoint mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies [published erratum appears in J Exp Med 1990 Aug 1;172(2):669]
The genetic mechanism responsible for the somatic diversification of two mAbs was determined. The two PC-binding hybridomas were representative of events early and late in the immune response. The P28 cell line that produces an IgM antibody and thus represents events early in the immune response, was found to have 3 bp changes in its heavy chain variable (VH) region, with some changes in antibo...
متن کاملAllelic variations in the human T cell receptor V beta 6.7 gene products [published erratum appears in J Exp Med 1990 Mar 1;171(3):973]
Polymorphisms of human TCR gene products have been suggested by the description of a mAb, OT145, that identifies a subset of TCRs in some individuals but not in others (6). Here we demonstrate that this mAb detects a TCR allotype of the V beta 6.7 gene. Two allelic products of this V gene differ by two nonconservative amino acid substitutions. The mAb OT145 appears to react with V beta 6.7 a ge...
متن کاملEndotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level [published erratum appears in J Exp Med 1990 Mar 1;171(3):971-2]
The biosynthesis of cachectin/TNF is largely regulated at a post-transcriptional level. Bacterial endotoxin, which strongly induces cachectin/TNF production, thus seems to elicit at least some of its effects by altering the macrophage cytoplasmic milieu. It has previously been shown that the 3'-untranslated TTATTTAT element present in numerous cytokines and proto-oncogenes is capable of repress...
متن کاملInterleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75 [published erratum appears in J Exp Med 1990 Jun 1;171(6):2183]
We have recently established a mAb named TU11 mAb specific for the p75 subunit of human IL-2 receptor (IL-2R). The present study using TU11 mAb demonstrates the IL-2-induced phosphorylation of IL-2Rp75 on tyrosine residues in IL-2-dependent T cells. The tyrosine phosphorylation is mediated by the high affinity IL-2R, correlates with the IL-2-induced cell growth, and rapidly increases during the...
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ژورنال
عنوان ژورنال: Academic Medicine
سال: 1990
ISSN: 1040-2446
DOI: 10.1097/00001888-199009000-00003