Development and Validation of RAPID: A Patient-Specific Monte Carlo Three-Dimensional Internal Dosimetry Platform

Implementation and evaluation of patient-specific three-dimensional internal dosimetry.

UNLABELLED Current methods for calculating the absorbed dose in a target region from a source region rely on a standard "reference man" geometry and assume an uniform distribution of radiolabel. While this approach is acceptable at the low levels of radioisotope administered for most diagnostic purposes, the generality of the calculations is not adequate for doses at the higher levels required ...

Development and implementation of a Monte Carlo frame work for evaluation of patient specific out- of - field organ equivalent dose

Background: The aim of this study was to develop and implement a Monte Carlo framework for evaluation of patient specific out-of-field organ equivalent dose (OED). Materials and Methods: Dose calculations were performed using a Monte Carlo-based model of Oncor linac and tomographic phantoms. Monte Carlo simulations were performed using EGSnrc user codes. Dose measurements were performed using r...

Rabbit internal dosimetry for iodine-131 using GATE Monte Carlo simulation code: a preclinical trial

Introduction: One of the main concerns in administration of radiotracers, especially in therapeutic arm, is the amount of delivered dose to the different organs. Individual variations of anatomy, physiology and underlying pathology in the patients lead to alteration of administered activity. In the current study we preclinically applied internal dosimetry using an animal mod...

Three-Dimensional Radiobiological Dosimetry (3D-RD): Application of Radiobiological Modeling to Patient-Specific, 3-D Imaging-based Internal Dosimetry

Bayesian internal dosimetry calculations using Markov Chain Monte Carlo.

A new numerical method for solving the inverse problem of internal dosimetry is described. The new method uses Markov Chain Monte Carlo and the Metropolis algorithm. Multiple intake amounts, biokinetic types, and times of intake are determined from bioassay data by integrating over the Bayesian posterior distribution. The method appears definitive, but its application requires a large amount of...