Development, characterization & invivo evaluation of proniosomal based transdermal delivery system of Atenolol
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چکیده
منابع مشابه
Design and Development of a Proniosomal Transdermal Drug Delivery System for Captopril
Purpose: The aim of the study was to develop a proniosomal carrier system for captopril for the treatment of hypertension that is capable of efficiently delivering entrapped drug over an extended period of time. Method: The potential of proniosomes as a transdermal drug delivery system for captopril was investigated by encapsulating the drug in various formulations of proniosomal gel composed o...
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INTRODUCTION: The age-old theory that imparted the status of “dead, impermeable barrier devoid of biological activity” to skin had already been challenged by the development of pioneering transdermal product, but a less than impressive commercial growth in this sector had raised some doubts about the feasibility of this route as an efficient device of drug delivery. The journey of transdermal r...
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Atenolol, an antihypertensive drug, has poor bioavailability (40-50%) and has has low elimination half life(6 hr). Atenolol is mainly absorbed in the stomach. The floating tablets of atenolol were prepared to increase the gastric retention, extend the drug release and to improve the bioavailability of the drug. The floating tablets were formulated using HPMC 100 cps, sodium alginate, carbopol 9...
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ژورنال
عنوان ژورنال: Future Journal of Pharmaceutical Sciences
سال: 2018
ISSN: 2314-7245
DOI: 10.1016/j.fjps.2017.10.003