Development of A Fecal Microbiota Transplant (FMT) Program for Relapsing Clostridium difficile Disease (CDAD)

Oral, frozen fecal microbiota transplant (FMT) capsules for recurrent Clostridium difficile infection

BACKGROUND Fecal microbiota transplantation (FMT) has been shown to be safe and effective in treating refractory or relapsing C. difficile infection (CDI), but its use has been limited by practical barriers. We recently reported a small preliminary feasibility study using orally administered frozen fecal capsules. Following these early results, we now report our clinical experience in a large c...

Clostridium difficile Infection and Fecal Microbiota Transplant.

Clostridium difficile infection (CDI) is a major source of morbidity and mortality for hospitalized patients. Although most patients have a clinical response to existing antimicrobial therapies, recurrent infection develops in up to 30% of patients. Fecal microbiota transplant is a novel approach to this complex problem, with an efficacy rate of nearly 90% in the setting of multiple recurrent C...

1798Oral, Frozen Fecal Microbiota Capsules for Relapsing Clostridium difficile Infection

1798. Oral, Frozen Fecal Microbiota Capsules for Relapsing Clostridium difficile Infection Ilan Youngster, MD; George Russell, MD; Christina Pindar,; Jenny Sauk, MD; Elizabeth Hohmann, MD; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA; Division of Infectious Diseases, Boston Children’s Hospital, Boston, MA...

Treatment of relapsing Clostridium difficile infection using fecal microbiota transplantation

BACKGROUND Clostridium difficile infection (CDI) has become a global concern over the last decade. In the United States, CDI escalated in incidence from 1996 to 2005 from 31 to 64/100,000. In 2010, there were 500,000 cases of CDI with an estimated mortality up to 20,000 cases a year. The significance of this problem is evident from the hospital costs of over 3 billion dollars annually. Fecal mi...

Weight Changes in Fecal Microbiota Transplant for Clostridium difficile