Development of elastin-like polypeptide for targeted specific gene delivery in vivo

Thermally Targeted Delivery of a c-Myc Inhibitory Peptide in Vivo Using Elastin-Like Polypeptide

Thermally Targeted Delivery of a c-Myc Inhibitory Peptide In Vivo Using Elastin-like Polypeptide PRINCIPAL INVESTIGATOR:

Article history: The therapeutic index of cur Received 30 July 2008 Accepted 11 November 2008 Available online xxxx

Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying.

The development of environmentally responsive drug carriers requires new methods for assembling stimuli-responsive nanoparticulates. This communication describes a novel application of electrospray to construct bioresponsive peptide-based particulates, which can encapsulate drugs. These particles are composed from genetically engineered elastin-like polypeptides (ELPs), a biodegradable, biocomp...

Intranasal administration of elastin-like polypeptide for therapeutic delivery to the central nervous system

Bypassing the blood-brain barrier is one of the primary considerations when designing compounds intended to function in the central nervous system (CNS). Intranasal (IN) administration of otherwise blood-brain barrier impermeable molecules can result in high CNS concentrations and low systemic accumulation, indicating that IN administration may be a useful method of delivering therapeutics to t...

Leukocyte Response to Elastin-like Polypeptide Coatings