Development of nonhuman adenoviruses as vaccine vectors
نویسندگان
چکیده
منابع مشابه
Simian adenoviruses as vaccine vectors
Replication incompetent human adenovirus serotype 5 (HAdV-C5) has been extensively used as a delivery vehicle for gene therapy proteins and infectious disease antigens. These vectors infect replicating and nonreplicating cells, have a broad tissue tropism, elicit high immune responses and are easily purified to high titers. However, the utility of HAdV-C5 vectors as potential vaccines is limite...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2006
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2005.08.101