Development of PLZF-expressing innate T cells
نویسندگان
چکیده
منابع مشابه
A transgenic TCR directs the development of IL-4+ and PLZF+ innate CD4 T cells.
MHC class II-expressing thymocytes can efficiently mediate positive selection of CD4 T cells in mice. Thymocyte-selected CD4 (T-CD4) T cells have an innate-like phenotype similar to invariant NKT cells. To investigate the development and function of T-CD4 T cells in-depth, we cloned TCR genes from T-CD4 T cells and generated transgenic mice. Remarkably, positive selection of T-CD4 TCR transgeni...
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PLZF-expressing invariant natural killer T cells and CD4 T cells are unique subsets of innate T cells. Both are selected via thymocyte-thymocyte interaction, and they contribute to the generation of activated/memory-like CD4 and CD8 T cells in the thymus via the production of IL-4. Here, we investigated whether PLZF(+) innate T cells also affect the development and function of Foxp3(+) regulato...
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In mice, the transcription factor, PLZF, controls the development of effector functions in invariant NKT cells and a subset of NKT cell-like, γδ T cells. Here, we show that in human lymphocytes, in addition to invariant NKT cells, PLZF was also expressed in a large percentage of CD8+ and CD4+ T cells. Furthermore, PLZF was also found to be expressed in all γδ T cells and in all NK cells. Import...
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Peripheral T-cell lymphomas (PTCL) are uncommon and account for ,10%of all non-Hodgkin lymphomas. Themost common category of PTCL is “not otherwise specified” (PTCL-NOS), reflecting the lack of specific parameters to define PTCL subsets in a biologically relevant way. Although it is recognized that PTCL arise from both adaptive and innate lymphoid cells, the precise cell of origin for most PTCL...
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The transcription factor PLZF (promyelocytic leukemia zinc finger; zbtb16) is essential for nearly all of the unique characteristics of NKT cells including their rapid and potent response to antigen. In the immune system, zbtb16 expression is only found in innate cells. Conventional T cells that ectopically express PLZF spontaneously acquire an activated, effector phenotype. Activation induced ...
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ژورنال
عنوان ژورنال: Current Opinion in Immunology
سال: 2011
ISSN: 0952-7915
DOI: 10.1016/j.coi.2010.12.016