Development of Sustained Release “NanoFDC (Fixed Dose Combination)” for Hypertension – An Experimental Study
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منابع مشابه
Development of Sustained Release “NanoFDC (Fixed Dose Combination)” for Hypertension – An Experimental Study
OBJECTIVES The present study was planned to formulate, characterize and evaluate the pharmacokinetics of a novel "NanoFDC" comprising three commonly prescribed anti-hypertensive drugs, hydrochlorothiazide (a diuretic), candesartan (ARB) and amlodipine (a calcium channel blocker). BASIC METHODS The candidate drugs were loaded in Poly (DL-lactide-co-gycolide) (PLGA) by emulsion- diffusion-evapo...
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Hypertension is the leading cause of disability and cardiovascular mortality world-wide. Approximately one-third of the US adult population and over a billion people world-wide have hypertension. Despite increased awareness of hypertension and availability of many effective antihypertensive agents, only one third of patients achieve their target blood pressure (BP). All expert panels now recomm...
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Hypertension remains uncontrolled in approximately 50% of patients with hypertension, which increases the risk of cardiovascular morbidity and mortality in these individuals. A key factor contributing to poor blood pressure (BP) control is nonadherence to prescribed antihypertensive medications. Improving patient adherence to antihypertensive therapy is the key to improving BP goal attainment. ...
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Blood pressure (BP) control is inadequate worldwide. Many clinical trials suggest that BP is not satisfactorily controlled using monotherapy in most patients. Free drug or fixed-dose combinations are other therapeutic options. The advantages and disadvantages for different treatment approaches are discussed in this review.
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0128208