Diagnostic and prognostic value of calcium oscillatory pattern analysis for patients with ICSI fertilization failure

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Diagnostic and prognostic value of calcium oscillatory pattern analysis for patients with ICSI fertilization failure.

STUDY QUESTION Does calcium oscillatory pattern analysis following heterologous intra-cytoplasmic sperm injection (ICSI) of human sperm into mouse oocytes lead to diagnostic and prognostic information for patients suffering from ICSI fertilization failure? SUMMARY ANSWER We found that calcium oscillatory pattern analysis following heterologous ICSI has the strength to reveal, for the individu...

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Treatment option for sperm- or oocyte-related fertilization failure: assisted oocyte activation following diagnostic heterologous ICSI.

BACKGROUND Failed fertilization occurs in 2-3% of ICSI cycles and is mainly due to lack of oocyte activation. Heterologous ICSI of patient's sperm in mouse oocytes allows discrimination between sperm- and oocyte-related aetiologies of activation failure. Assisted oocyte activation (AOA) by Ca-ionophore treatment can initiate fertilization in subsequent therapeutic ICSI. We report on diagnosis a...

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ژورنال

عنوان ژورنال: Human Reproduction

سال: 2012

ISSN: 1460-2350,0268-1161

DOI: 10.1093/humrep/des368