DIFFERENCE BETWEEN NEUTROPHIL TO LYMPHOCYTE RATIO (NLR) BETWEEN LUPUS PATIENTS WITH AND WITHOUT NEPHRITIS

Neutrophil to lymphocyte ratio (NLR) can be a potential biomarker for disease activity and prognosis in the development of systemic lupus erythematosus (SLE). AIM: determine if there are difference between NLR value patient with nephritis without nephritis. METHOD: The subjects this study were patients SLE diagnosis Dr. Hasan Sadikin General Hospital Bandung during period January December 2019. selected statistical test was non-parametric Mann-Whitney test, analysis receiver operating curve (ROC) conducted obtain cut-off predicting Data processing using SPSS® software version 20.0. RESULTS: total obtained data 156 patients. There significant (median 4.20, while median 2.82, p <0001, >3.52 sensitivity 67.6%, specificity 67.1% distinguishing DISCUSSION: Lupus marked by deposition immune complex kidney, which would activate complement system inflammatory cells such as neutrophils, monocytes, eosinophils T-lymphocytes. CONCLUSIONS: On study, it that on yielded <0.05. However, has not been determined parameter (flare-ups) prognosis.