Different Relations Between Infarct Size and Occluded Bed Size in Barbiturate-Anesthetized Versus Conscious Dogs
نویسندگان
چکیده
منابع مشابه
Comparison of three different A1 adenosine receptor antagonists on infarct size and multiple cycle ischemic preconditioning in anesthetized dogs.
A(1) adenosine receptor (AR) antagonists are effective diuretic agents that may be useful for treating fluid retention disorders including congestive heart failure. However, antagonism of A(1)ARs is potentially a concern when using these agents in patients with ischemic heart disease. To address this concern, the present study was designed to compare the actions of the A(1)AR antagonists CPX (1...
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We compared myocardial infarct size produced by permanent occlusion of the middle left anterior descending (LAD) or circumflex (LCx) coronary artery in the anesthetized dog. The dogs were killed 3-10 days later, and the occluded coronary bed was visualized by postmortem arteriography. The outlines of the infarct and occluded bed were marked on tracings of weighed left ventricular (LV) rings and...
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Background. Short-term cholesterol feeding has been shown to affect vasomotor tone and increase infarct size in anesthetized rabbits. The purpose of the study was to determine whether acute hypercholesterolemia reduced collateral flow to ischemic myocardium and increased infarct size in the awake dog. Methods and Results. Acute myocardial infarction was produced in awake dogs by a 4-hour left a...
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We studied the effects of prortaglandin PGE,, PGE,, and prostacyclin (PGIa) on collateral blood flow (CBF) and myocardial infarct size in conscious dogs. Beginning 5 minutes after acute permanent occlusion of the mid left circumflex coronary artery, 6-hour infusions of PGEi (0.6 ag/kg per min in 150 saline, 13 dogs), PGE, (0.7 /ig/kg per min in 150 ml saline, 11 dogs), PGI, (0.5 /ig/kg per min ...
متن کاملMeasurement of nasal patency in anesthetized and conscious dogs.
Experiments were undertaken to characterize a noninvasive chronic, model of nasal congestion in which nasal patency is measured using acoustic rhinometry. Compound 48/80 was administered intranasally to elicit nasal congestion in five beagle dogs either by syringe (0.5 ml) in thiopental sodium-anesthetized animals or as a mist (0.25 ml) in the same animals in the conscious state. Effects of mas...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1985
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(85)80306-5