Differentiating germinal center-derived lymphomas through their cellular microenvironment
نویسندگان
چکیده
منابع مشابه
Investigation of potential traces of pluripotency in germinal-center-derived B-cell lymphomas driven by MYC
Human pluripotent stem cells (hPSCs) are defined by their indefinite self-renewal in vitro and their potential to differentiate into cells representative of all lineages of the mammalian gastrulation embryo. Several similarities link these genomically normal cells with features salient to malignancies, for example, when injected into immunodeficient mice, hPSCs give rise to tumors closely resem...
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GCET1 (germinal center B cell-expressed transcript-1) gene codes for a serpin expressed in germinal center (GC) B cells. Following the observation that follicular lymphoma cases exhibit an increased level of Gcet1 expression, compared with follicular hyperplasia, we have characterized Gcet1 protein expression in human tissues, cell lines, and a large series of lymphomas. To this end, we have pe...
متن کاملComparison of germinal center markers CD10, BCL6 and human germinal center-associated lymphoma (HGAL) in follicular lymphomas
BACKGROUND Recently, human germinal center-associated lymphoma (HGAL) gene protein has been proposed as an adjunctive follicular marker to CD10 and BCL6. METHODS Our aim was to evaluate immunoreactivity for HGAL in 82 cases of follicular lymphomas (FLs)--67 nodal, 5 cutaneous and 10 transformed--which were all analysed histologically, by immunohistochemistry and PCR. RESULTS Immunostaining ...
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BACKGROUND Research on the origins and development of human IgE-expressing (IgE(+) ) cells is required for understanding the pathogenesis of allergy and asthma. These studies have been thwarted by the rarity of IgE(+) cells in vivo and the low frequency of class switch recombination (CSR) to IgE ex vivo. To determine the main source of IgE(+) cells, we investigated the relation between the phen...
متن کاملIdentification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas.
Germinal centers (GCs) are sites of B-cell clonal expansion, hypermutation, and selection. GCs are polarized into dark (DZ) and light zones (LZ), a distinction that is of key importance to GC selection. However, the difference between the B cells in each of these zones in humans remains unclear. We show that, as in mice, CXCR4 and CD83 can be used to distinguish human LZ and DZ cells. Using the...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2009
ISSN: 0361-8609,1096-8652
DOI: 10.1002/ajh.21434