Diffusion MR of hyperpolarized 13C molecules in solution

Diffusion MR of hyperpolarized 13C molecules in solution.

We combined the high MR signal enhancement achieved using dissolution dynamic nuclear polarization (DNP) with a pulsed gradient double spin echo diffusion MR sequence to rapidly and accurately measure the diffusion coefficients of various hyperpolarized (13)C molecules in solution. Furthermore, with a diffusion-weighted imaging sequence we generate diffusion coefficient maps of multiple hyperpo...

Noninvasive Assessment of Renal Tumor Aggressiveness Using Hyperpolarized 13C MR

13C Hyperpolarized Anticoagulants

J. Bargon, J. Bernarding, R. Rizi, H-W. Spiess, K. Münnemann, M. Roth, and U. Bommerich Institute of Physical and Theoretical Chemistry, University of Bonn, Bonn, NRW, Germany, Institute of Biometry, University of Magdeburg, Magdeburg, Germany, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States, NMR, Max-Planck Institute of Polymers, Mainz, Germany, I...

Measuring diffusion of xenon in solution with hyperpolarized Xe NMR

129 Ž . A hyperpolarized Xe Nuclear Magnetic Resonance NMR technique for measuring diffusion of xenon in solution is presented. The dramatically enhanced NMR signal of hyperpolarized Xe makes it possible to measure the xenon self-diffusion coefficient with a single-shot NMR experiment. Diffusion constants of xenon in various solvents are reported. Ž . y5 2 y1 A value of 2.2"0.4 =10 cm s was mea...

Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging.

PURPOSE To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model. MATERIALS AND METHODS Twenty athymic rats with intracranial implantation of human glioblastoma cells were divided into two groups: one group received an oral administration of 100 mg/kg TMZ (n = 10...