Digital Health Integration With Neuromodulation Therapies: The Future of Patient-Centric Innovation in Neuromodulation

Neuromodulation therapies and treatment-resistant depression

BACKGROUND Patients with treatment-resistant depression (TRD) who showed partial response to pharmacological and psychotherapeutic interventions need a trial of neuromodulation therapies (NTs). OBJECTIVE This paper aims to review evidence-based data on the use of NTs in TRD. METHOD Using keywords and combined-word strategy, multiple computer searches of PubMed, Google Scholar, Quertle(R), a...

Neuromodulation and neurostimulation: overview and future potential

Neuromodulation in

s are only included if they are not published later on in full article format. Abbreviations: IED,interictal epileptiform discharges; VNS, vagus nerve stimulation; 3-MPA, 3-mercaptoproprionate;PTZ, pentylenetetrazol; MES, maximal electroshock seizure; SWDs, spike and wave discharges; ADD,afterdischarge duration. Zanchetti et al. (1952) were among the first to experiment with the ant...

Neuromodulation Section

Objective. Spinal cord and peripheral neurostimulation techniques have been practiced since 1967 for the relief of pain, and some techniques are also used for improvement in organ function. Neuromodulation has recognized complications, although very rarely do these cause long-term morbidity. The aim of this article is to present a review of complications observed in patients treated with neuros...

Neuromodulation of Neuronal Circuits: Back to the Future

All nervous systems are subject to neuromodulation. Neuromodulators can be delivered as local hormones, as cotransmitters in projection neurons, and through the general circulation. Because neuromodulators can transform the intrinsic firing properties of circuit neurons and alter effective synaptic strength, neuromodulatory substances reconfigure neuronal circuits, often massively altering thei...