Diosgenin-induced physicochemical effects on phospholipid bilayers in comparison with cholesterol
نویسندگان
چکیده
Diosgenin (DGN), which is a sterol occurring in plants of the Dioscorea family, has attracted increasing attention for its various pharmacological activities. DGN structural similarity to cholesterol (Cho). In this study we investigated effects common tetracyclic cores and different side chains on physicochemical properties lipid bilayer membranes. Differential scanning calorimetry showed that Cho reduce phase transition enthalpy similar extent. 2H NMR, deuterated-DGN/Cho POPC ordering bilayers, revealed oriented parallel membrane normal like Cho. It was suggested affinity DGN-Cho stronger than DGN-DGN or Cho-Cho interaction. 31P NMR bilayers that, unlike Cho, altered interactions headgroups at 30 mol%. These results suggest below mol% with basic biomembrane properties.
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2021
ISSN: ['1464-3405', '0960-894X']
DOI: https://doi.org/10.1016/j.bmcl.2021.127816