Dipole Moment and Anticancer Activity of Beta Lactams
نویسندگان
چکیده
This study investigates the correlation between in vitro anticancer activity and dipole moments of beta lactams by calculating moment with five different semiempirical methods (Austin model 1/Recife 1/Parametric number 3/Parametric 6/ Modified neglect differential overlap). Dipole value is analyzed to identify a experimental lactams. To best our knowledge, this first report on relationship activities Six lactam compounds are considered for study. It observed that active have significantly higher (ranging from 5.12 4.3) compared inactive 3.8 2.29). These data indicate might be useful parameter estimation biological also aims determine most prominent descriptor cytotoxic aid development more agents.
منابع مشابه
Selective anticancer activity of β-lactams derived from polyaromatic compound.
Currently available anticancer drugs are cytotoxic to normal as well as to neoplastic cells, therefore the synthesis of β-lactams as new and novel anticancer agents is extremely significant. We previously developed synthetic methods for the preparation of β-lactams and anticancer agents resulting from polyaromatic amines. There have also been reports on the synthesis and biological evaluation o...
متن کاملBeta-lactams and their potential use as novel anticancer chemotherapeutics drugs.
The discovery of natural and synthetic antibiotics is one of the most important medical breakthroughs in human history. Many diseases, such as bacterial meningitis, pneumonia, and septicemia, are now curable with the use of antibiotics. Antibiotics are efficacious, generally well tolerated in patients, and have a low toxicity level. It is for these reasons antibiotics remain an attractive targe...
متن کاملantioxidant and antimicrobial activity of allium jesdianum extract
چکیده بررسی فعالیت ضد اکسیدانی و ضدمیکروبی عصاره گیاه بن سرخ (allium jesdianum) به کوشش: زهرا مقیمی هدف از این تحقیق بررسی میزان ترکیبات فنولی کل، ترکیبات فلاوونوئیدی کل، فعالیت ضداکسیدانی و ضدمیکروبی عصاره ی گیاه تازه و خشک بن سرخ بود. استخراج عصاره به روش های غوطه وری، استفاده از همزن مغناطیسی، دستگاه مایکروویو، امواج فراصوت و گرمادهی مقاومتی و با استفاده از متانول، اتانول و آب به عنوا...
Neutron Electric Dipole Moment Experiments
The possibility of a non-zero value for neutron EDM continues to be of central importance in physics and cosmology. A non-zero neutron EDM would be a direct evidence for time-reversal symmetry violation. It also implies CP-violation under the assumption of CPT invariance. To date, only two examples of CP-violation have been found: decays of neutral K mesons and B mesons. CP-violation is believe...
متن کاملThe Muon Electric Dipole Moment
The electric dipole moment of the muon (dμ) is evaluated in a two Higgs doublet model with a softly broken discrete symmetry. For tan β ≡ |v2|/|v1| ∼ 1, contributions from two loop diagrams involving the t quark and the W boson dominate; while for tan β ∼ > 10, contributions from two loop diagrams involving the b quark and the τ lepton are dominant. For 8 ∼ > tan β ∼ > 4, significant cancellati...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2021
ISSN: ['0250-474X', '1998-3743']
DOI: https://doi.org/10.36468/pharmaceutical-sciences.862