Direct Bone Resorption by Macrophages
نویسندگان
چکیده
منابع مشابه
Direct stimulation of bone resorption by thyroid hormones.
Although hypercalcemia, osteoporosis, and increased bone turnover are associated with thyrotoxicosis, no direct effects of thyroid hormones on bone metabolism have been reported previously in organ culture. We have now demonstrated that prolonged treatment with thyroxine (T4) or triiodothyronine (T3) can directly increase bone resorption in cultured fetal rat long bones as measured by the relea...
متن کاملMacrophages stimulate bone resorption when they phagocytose particles.
We investigated in vitro a mechanism by which particulate debris may induce bone resorption and cause implant loosening. We first studied two standard particles: latex, which is considered to be inert, and zymosan, which is inflammatory. Macrophages that phagocytosed either particle became activated, and stimulated 15 times as much bone resorption as did control macrophages. For activation to o...
متن کاملGenistein prevents bone resorption diseases by inhibiting bone resorption and stimulating bone formation.
UNLABELLED Genistein, a soybean-derived isoflavone, has been shown to suppress osteoclastic bone resorption. To clarify the mechanisms underlying this action, we investigated the effects of genistein on the differentiation, cytoskeleton and function in mice osteoclasts in vitro and bone metabolism in ovariectomized rats. STUDY DESIGN Primary OCs were isolated from 3 week-old mice and induced ...
متن کاملHuman osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis.
OBJECTIVE To determine whether synovial macrophages and monocytes isolated from patients with rheumatoid arthritis patients are capable of differentiating into osteoclastic bone resorbing cells; and the cellular and humoral conditions required for this to occur. METHODS Macrophages isolated from the synovium and monocytes from the peripheral blood of rheumatoid arthritis patients were culture...
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ژورنال
عنوان ژورنال: Japanese Journal of Clinical Immunology
سال: 1983
ISSN: 0911-4300,1349-7413
DOI: 10.2177/jsci.6.160