Direct ChIP-Seq significance analysis improves target prediction
نویسندگان
چکیده
منابع مشابه
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The access of transcription factors and the replication machinery to DNA is regulated by the epigenetic state of chromatin. In eukaryotes, this complex layer of regulatory processes includes the direct methylation of DNA, as well as covalent modifications to histones. Using next-generation sequencers, it is now possible to obtain profiles of epigenetic modifications across a genome using chroma...
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Next generation sequencing (NGS) technologies have opened up novel research possibilities in many areas including cancer research, gene regulation, epigenetics, personalized medicine and pharmacogenomics. ChIP-seq is a remarkable NGS-based approach to uncover functional features of the DNA on a genome-wide scale and in great detail. A major application area of ChIP-seq is the discovery of trans...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2015
ISSN: 1471-2164
DOI: 10.1186/1471-2164-16-s5-s4