Discovery and development of alectinib hydrochloride (ALECENSAR capsule 20 mg and 40 mg)
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چکیده
منابع مشابه
Ezetimibe/simvastatin 10/20 mg versus simvastatin 40 mg in coronary heart disease patients.
BACKGROUND Reducing low-density lipoprotein cholesterol (LDL-C) is the primary goal of therapy in patients with hypercholesterolemia and coronary heart disease (CHD). METHODS This double blind placebo-controlled study enrolled patients 18 to 75 years of age with primary hypercholesterolemia and established CHD who were taking a stable daily dose of simvastatin 20 mg. Patients were randomized ...
متن کاملBasal, sham feed and pentagastrin stimulated gastric acid, pepsin and electrolytes after omeprazole 20 mg and 40 mg daily.
Gastric secretion was measured in nine patients with duodenal ulcer before, and after treatment for four weeks with omeprazole 20 mg or 40 mg daily. Basal acidity and acid output were affected variably by 20 mg, but inhibited totally by 40 mg daily. Sham feed stimulated acid output was reduced by 20 mg daily and completely inhibited by 40 mg daily. Maximal pentagastrin stimulated acid output wa...
متن کاملFormulation Development of Generic Omeprazole 20 mg Enteric Coated Tablets
Omeprazole is a potent proton pump inhibitor with powerful inhibition of secretion of gastric juice. Oral site-specific drug delivery systems have recently attracted a great interest for the local treatment of bowel disease and for improving systemic absorption of drugs which are unstable in the stomach. However, microenvironment in the gastrointestinal tract and varying absorption mechanisms c...
متن کاملNifedipineExtended-release Tablets, USP30 mg, 60 mg and 90 mg
Nifedipine Extended-release Tablet depends for its action on the existence of an osmotic gradient between the contents of the tablet core and fluid in the GI tract. Drug delivery is essentially constant as long as the osmotic gradient remains constant, and then gradually falls to zero. Upon swallowing, the biologically inert components of the tablet remain intact during GI transit and are elimi...
متن کاملBioequivalence Evaluation of Two Esomeprazole 20 mg Capsule Formulations in Healthy Male Bangladeshi Volunteers
Esomeprazole, the S-isomer of omeprazole was developed with the aim of improving the pharmacokinetic and pharmacodynamic profiles of racemic omeprazole [1]. It suppresses the secretion of hydrochloric acid from gastric parietal cells via inhibition of the H+/K+ adenosine triphosphatase enzyme like other proton pump inhibitors [2]. Among all proton pump inhibitors available, esomeprazole is the ...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2015
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.145.318