Discovery of dual function acridones as a new antimalarial chemotype
نویسندگان
چکیده
منابع مشابه
Salinipostins A-K, long-chain bicyclic phosphotriesters as a potent and selective antimalarial chemotype.
Despite significant advances in antimalarial chemotherapy over the past 30 years, development of resistance to frontline drugs remains a significant challenge that limits efforts to eradicate the disease. We now report the discovery of a new class of antimalarials, salinipostins A-K, with low nanomolar potencies and high selectivity indices against mammalian cells (salinipostin A: Plasmodium fa...
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ژورنال
عنوان ژورنال: Nature
سال: 2009
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature07937